Ribose 5-phosphate → D-Ribitol 5-phosphate

HRID 493053

반응식

HRID 493053 반응식
[Na].[P:2]([O:6][CH2:7][C@@H:8]([OH:15])[C@@H:9]([OH:14])[C@@H:10]([OH:13])[CH:11]=[O:12])([OH:5])([OH:4])=[O:3].[BH4-].[Na+]>CO>[P:2]([O:6][CH2:7][C@@H:8]([OH:15])[C@@H:9]([OH:14])[C@@H:10]([OH:13])[CH2:11][OH:12])([OH:4])([OH:5])=[O:3]

참가 물질

5

반응물 3

HCID 77982Ribose 5-phosphateHCID 4311764Sodium borohydrideHCID 5360545Sodium

생성물 1

HCID 151104D-Ribitol 5-phosphate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The sodium salt of D-ribose 5-phosphate (18.5 mg, 67.5 μmol) is dissolved in methanol (600 μl, 40% (v/v)). Sodium borohydride is added. The reaction is monitored by detection of the aldehyde according to the method of Stahl (Bollinger, H. R., Brenner, M., Gänshirt, H., Mangold, H. K., Seiler, H., Stahl, E. ad Waldi, D. (1964) IN: Dünnschicht-Chromatographie; Ein Laboratoriumshandbuch (ed. Stahl, E.) Springer Verlag, Berlin, Göttingen; Heidelberg). After consumption of the aldehyde the pH of the solution is adjusted with acetic acid to 4-5. The reaction mixture is lyophillized yielding D-ribitol 5-phosphate as a dry compound.

후처리

  1. customAfter consumption of the aldehyde the pH of the solution

출처 및 근거

ORD 기록
ord-307e5ed24906437babd1f6703a23eb5b
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07534742B2

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