Sodium Iodide → 84422-52-6

HRID 493208

반응식

HRID 493208 반응식
C[O:2][C:3]1[CH:10]=[C:9]([O:11][CH3:12])[C:8]([CH3:13])=[CH:7][C:4]=1[CH:5]=[O:6].[I-].[Na+].[Al+3].[Cl-].[Cl-].[Cl-]>C(#N)C>[OH:2][C:3]1[CH:10]=[C:9]([O:11][CH3:12])[C:8]([CH3:13])=[CH:7][C:4]=1[CH:5]=[O:6]

참가 물질

5

반응물 3

HCID 5238Sodium IodideHCID 2516922,4-Dimethoxy-5-methylbenzaldehydeHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 1316681984422-52-6

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

The above prepared 2,4-Dimethoxy-5-methyl-benzaldehyde (5.40 g, 30 mmol) was dissolved in 150 mL of acetonitrile and treated successively with sodium iodide (6.74 g, 1.5 eq.) and AlCl3 (4.00 g, 1.0 eq.), and the mixture kept at 80° C. for 1 h. Cooling, pouring onto crashed ice, twofold extraction with AcOEt, washing with water and brine, drying over magnesium sulfate, and evaporation of the solvents, followed by flash chromatography (SiO2, hexane/AcOEt=9/1), delivered 4.23 g of the title compound as light brown crystals.

후처리

  1. temperatureCooling
  2. additionpouring
  3. extractionice, twofold extraction with AcOEt
  4. washwashing with water and brine
  5. dry with materialdrying over magnesium sulfate, and evaporation of the solvents

출처 및 근거

ORD 기록
ord-11a5a2acbeae4b778a041cb41b2954dc
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07534788B2

연결된 노트

불러오는 중…