Hydrochloric Acid → 6-Hydroxyquinoline-2-carboxylic acid

HRID 493423노트

반응식

HRID 493423 반응식
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([C:13]([OH:15])=[O:14])[CH:7]=[CH:6]2.[OH-].[NH4+].Cl>Br.O>[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([C:13]([OH:15])=[O:14])[CH:7]=[CH:6]2

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14923Ammonium HydroxideHCID 111832986-methoxyquinoline-2-carboxylic Acid

생성물 1

HCID 133367806-Hydroxyquinoline-2-carboxylic acid

시약·촉매·용매 2

HCID 260Hydrogen Bromide용매HCID 962Water용매

반응 조건

온도
125 °C

실험 절차

6-Methoxy-quinoline-2-carboxylic acid (4 g, 0.019 mol) was suspended in hydrobromic acid 48% in water (80 ml) and the mixture was heated at 125° C. overnight. After cooling to 0° C. ammonium hydroxide was added until the pH was 6-7 followed by addition of HCl until the pH was 3-4 and the compound precipitated. The solid was filtrated, washed with water and dried under vacuum to yield 3.5 g (0.0185 mol, 97% of theory) of the title compound as a yellow solid MS (m/e)=190.1 (M+H)+.

후처리

  1. additionwas added until the pH was 6-7
  2. customthe compound precipitated
  3. filtrationThe solid was filtrated
  4. washwashed with water
  5. customdried under vacuum

출처 및 근거

ORD 기록
ord-9c87f3eaade24b8497bce2b060f9057e
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07534891B2

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