Hydrogen Bromide → 4-Hydroxy-4'-nitrobiphenyl

HRID 493512

반응식

HRID 493512 반응식
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.Br>C(O)(=O)C>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 111280794-Methoxy-4'-nitrobiphenyl

생성물 1

HCID 1380784-Hydroxy-4'-nitrobiphenyl

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
120 °C

실험 절차

4′-Methoxy-4-nitro-biphenyl (4.55 g, 19.8 mmol), prepared in the previous step, in a mixture of glacial acetic acid plus 65 mL of 48% HBr was heated at approximately 120° C. until the reaction was complete by TLC. The reaction was concentrated under reduced pressure and the residue partitioned between diethyl ether and water. The organic layer was separated, dried (Na2SO4) and the solvent removed under reduced pressure to give 4′-hydroxy-4-nitro-biphenyl.

후처리

  1. concentrationThe reaction was concentrated under reduced pressure
  2. customthe residue partitioned between diethyl ether and water
  3. customThe organic layer was separated
  4. dry with materialdried (Na2SO4)
  5. customthe solvent removed under reduced pressure

출처 및 근거

ORD 기록
ord-b96104b8c75c422aacbc263d6a4065c5
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07534894B2

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