Hydrochloric Acid → Ethyl 2-(piperidin-4-yl)acetate

HRID 4949

반응식

HRID 4949 반응식
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:3][CH:2]=1.Cl>C(O)C.[H][H].[Pt]=O>[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:3][CH2:2]1

참가 물질

6

반응물 2

HCID 313Hydrochloric AcidHCID 736321Ethyl pyridine-4-acetate

생성물 1

HCID 2760465Ethyl 2-(piperidin-4-yl)acetate수율 162.3%

시약·촉매·용매 3

HCID 82844Platinum oxide (PtO)촉매HCID 702Ethanol용매HCID 178418361HCID 178418361, 화합물용매

실험 절차

16.5 g (0.1 mol) Ethyl 4-pyridylacetate, 8.4 mL (0.1 mol) 12N hydrochloric acid and 2.5 g platinum oxide were dissolved in absolute ethanol and hydrogenated at 40 psi hydrogen on a Parr shaker. After 1 hour, the contents of the vessel were filtered and concentrated in vacuo yielding 27.79 g of ethyl 4-piperidinylacetate.

후처리

  1. filtrationthe contents of the vessel were filtered
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-4bf57d14da074ba286dc99dcf47db4ab
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05242924

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