Benzaldehyde → HCID 69497995, 화합물

HRID 495320

반응식

HRID 495320 반응식
[C:1]1(=[O:6])[CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-:7].[Na+].[CH:9](=O)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[O:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH:18]1[O:23][C:24]1[CH:31]=[CH:30][C:27]([CH:28]=O)=[CH:26][CH:25]=1>C(O)C.O>[O:7]1[CH2:5][CH2:4][CH2:3][CH2:2][CH:1]1[O:6][C:13]1[CH:14]=[CH:15][C:10]([CH:9]=[C:2]2[CH2:3][CH2:4][C:5](=[CH:28][C:27]3[CH:30]=[CH:31][C:24]([O:23][CH:18]4[CH2:19][CH2:20][CH2:21][CH2:22][O:17]4)=[CH:25][CH:26]=3)[C:1]2=[O:6])=[CH:11][CH:12]=1

참가 물질

7

반응물 4

HCID 240BenzaldehydeHCID 8452CyclopentanoneHCID 14798Sodium HydroxideHCID 112527364-(2-Tetrahydro-2H-pyranoxy)benzaldehyde

생성물 1

HCID 69497995HCID 69497995, 화합물수율 74%

시약·촉매·용매 2

HCID 702Ethanol용매2회HCID 962Water용매

실험 절차

Cyclopentanone (8.8 ml, 0.099 mol) was dissolved in ethanol (12 ml) and added to NaOH dissolved in water (25 ml) and ethanol (7 ml), and was left to stir for 25 min. This was then added to the THP protected benzaldehyde from 1CW01 (46.12 g, 0.22 mol), and the mixture was left to stir at room temperature for approximately 16 hours. A solid precipitate was isolated by vacuum filtration, washed with water (2×50 ml) and then ethanol (4×40 ml). This solid was recrystallised from ethanol to give a yellow solid (33.74 g, 74%).

후처리

  1. additionThis was then added to the THP
  2. waitthe mixture was left
  3. stirringto stir at room temperature for approximately 16 hours
  4. customA solid precipitate was isolated by vacuum filtration
  5. washwashed with water (2×50 ml)
  6. customThis solid was recrystallised from ethanol

출처 및 근거

ORD 기록
ord-0dc7a94483894b17b716ed6beacbeb41
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06939479B2

연결된 노트

불러오는 중…