4-Chlorobutyryl chloride → 1,4-Benzodioxan

HRID 4954

반응식

HRID 4954 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:13]=2)[NH:8][CH:7]=1.[CH2:20]([O:22][C:23]([C:25]1[CH:26]=[C:27]2[C:31](=[CH:32][CH:33]=1)NC=C2)=[O:24])[CH3:21].[Cl:34][CH2:35][CH2:36][CH2:37][C:38](Cl)=[O:39]>CC(C)=O.O>[Cl:34][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:13]=2)[NH:8][CH:7]=1.[C:23]1(=[O:24])[N:1]([CH2:2][CH2:3][CH2:4][CH2:5][C:6]2[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:13]=3)[NH:8][CH:7]=2)[C:38](=[O:39])[C:33]2=[CH:32][CH:31]=[CH:27][CH:26]=[C:25]12.[O:22]1[C:37]2[CH:36]=[CH:35][CH:2]=[CH:3][C:38]=2[O:39][CH2:21][CH2:20]1

참가 물질

8

반응물 3

HCID 783704-Chlorobutyryl chlorideHCID 10987040Ethyl indole-5-carboxylateHCID 197973473-(4-Aminobutyl)-5-ethoxycarbonylindole

생성물 3

HCID 103011,4-BenzodioxanHCID 194388633-(4-Chlorobutyl)-5-ethoxycarbonylindoleHCID 197973433(4-Phthalimidobutyl)-5-ethoxycarbonylindole

시약·촉매·용매 2

HCID 180Acetone용매HCID 962Water용매

실험 절차

A mixture of 2.18 g of 3-(4-aminobutyl)-5-ethoxycarbonylindole [obtainable from 5-ethoxycarbonylindole by reaction with 4-chlorobutyryl chloride, reduction of the product to give 3-(4-chlorobutyl)-5-ethoxycarbonylindole and conversion into 3(4-phthalimidobutyl)-5-ethoxycarbonylindole] and one equivalent of 6-N,N-bis(2-chloroethyl)amino)-1,4-benzodioxane ("B") in 40 ml of acetone and 40 ml of water is boiled for 24 hours and worked up in the conventional manner. 6-[4-(4-(5-ethoxycarbonylindol-3-yl)butyl)piperazino]-1,4-benzodioxane is obtained.

출처 및 근거

ORD 기록
ord-cd278516758a47cb98650ef6509a3367
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05242925

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