Hydrochloric Acid → 6-(4-Piperidinyl)-4H-benzo[1,4]oxazin-3-one

HRID 495422

반응식

HRID 495422 반응식
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:8]=[CH:9][C:10]3[O:15][CH2:14][C:13](=[O:16])[NH:12][C:11]=3[CH:17]=2)=[CH:3][CH:2]=1.Cl>CO.CCOCC.[Pt](=O)=O>[NH:1]1[CH2:2][CH2:3][CH:4]([C:7]2[CH:8]=[CH:9][C:10]3[O:15][CH2:14][C:13](=[O:16])[NH:12][C:11]=3[CH:17]=2)[CH2:5][CH2:6]1

참가 물질

6

반응물 2

HCID 313Hydrochloric AcidHCID 223266866-(4-Pyridyl)-4H-benzo[1,4]oxazin-3-one

생성물 1

HCID 223267216-(4-Piperidinyl)-4H-benzo[1,4]oxazin-3-one수율 100.8%

시약·촉매·용매 3

HCID 345198Adams' catalyst촉매HCID 887Methanol용매HCID 3283Diethyl Ether용매

실험 절차

A solution of 6-(4-pyridyl)-4H-benzo[1,4]oxazin-3-one (0.57 g, 2.52 mmol), in methanol (15 mL) was treated with platinum (IV) oxide (50 mg, 0.22 mmol) and 1M HCl in ether (2.7 mL) and stirred at room temperature under an atmosphere of hydrogen for 24 h. The reaction mixture was filtered through celite and the filtrate evaporated in vacuo to give the title compound (0.59 g, 87%) as a pale yellow solid.

후처리

  1. filtrationThe reaction mixture was filtered through celite
  2. customthe filtrate evaporated in vacuo

출처 및 근거

ORD 기록
ord-aab42d12505d4aff9039aae1fb862f60
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06939871B2

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