Sodium Hydroxide → 3-[5-(3-Aminopropyl)pyridin-2-yl]propylamine

HRID 49578노트

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HRID 49578 반응식
C([NH:3][CH2:4][CH2:5][CH2:6][C:7]1[CH:8]=[CH:9][C:10]([CH2:13][CH2:14][CH2:15][NH:16]C=O)=[N:11][CH:12]=1)=O.[OH-].[Na+]>Cl>[NH2:3][CH2:4][CH2:5][CH2:6][C:7]1[CH:8]=[CH:9][C:10]([CH2:13][CH2:14][CH2:15][NH2:16])=[N:11][CH:12]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 11161008N-(3-{5-[3-(Formylamino)propyl]pyridin-2-yl}propyl)formamide

생성물 1

HCID 98130173-[5-(3-Aminopropyl)pyridin-2-yl]propylamine

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

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온도
2.5 °C

실험 절차

A solution of N-(3-{5-[3-(formylamino)propyl]pyridin-2-yl}propyl)formamide (13-1) (13.25 g) in 6N HCl (100 mL) was refluxed for 1.5 h. The solution was cooled to 0-5° C. and the pH was adjusted to pH 12.5 with 50% sodium hydroxide (35 mL). The solution was extracted three times with s-BuOH, the extracts were combined, and the solvent was switched to toluene. The solution contained 10.0 g of the title compound 12-1 as determined by HIPLC assay.

후처리

  1. extractionThe solution was extracted three times with s-BuOH

출처 및 근거

ORD 기록
ord-1ce3a8c9ae9e471e91fc04e822f9513c
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06706885B2

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