Acetic Acid → 2-Acetoxy-3-bromo-tetrahydropyran

HRID 49579노트

반응식

HRID 49579 반응식
C1C(=O)N([Br:8])C(=O)C1.[O:9]1[CH:14]=[CH:13][CH2:12][CH2:11][CH2:10]1.[C:15]([OH:18])(=[O:17])[CH3:16]>C(OCC)C>[C:15]([O:18][CH:14]1[CH:13]([Br:8])[CH2:12][CH2:11][CH2:10][O:9]1)(=[O:17])[CH3:16]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 80803,4-dihydro-2H-pyranHCID 67184N-bromobutanimide

생성물 1

HCID 122985732-Acetoxy-3-bromo-tetrahydropyran수율 73%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To the solution of N-bromosuccimide (4.5 g ) in acetic acid (14.5 ml), was added dropwise 2.3 ml of 3,4-dihydro-2H-pyran at 10° C. The reaction mixture was diluted with 50 ml of diethyl ether and washed with 50 ml of water three times. The organic layer was washed with 1N NaHCO3 solution, dried, and then concentrated under a reduced pressure to give 4.1 g of 2-acetoxy-3-bromo-tetrahydropyran as a colorless oil (yield: 73%).

후처리

  1. washwashed with 50 ml of water three times
  2. washThe organic layer was washed with 1N NaHCO3 solution
  3. customdried
  4. concentrationconcentrated under a reduced pressure

출처 및 근거

ORD 기록
ord-e8b7fdd7e15b4edca43e03658d05f9d4
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06706888B2

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