Sodium Hydroxide → 2-Amino-5-(1-hydroxyiminoethyl)benzenesulfonamide
반응식
[C:1]([C:4]1[CH:5]=[CH:6][C:7]([NH2:14])=[C:8]([S:10]([NH2:13])(=[O:12])=[O:11])[CH:9]=1)(=O)[CH3:2].[NH2:15][OH:16].Cl.[OH-].[Na+]>CCO>[NH2:14][C:7]1[CH:6]=[CH:5][C:4]([C:1](=[N:15][OH:16])[CH3:2])=[CH:9][C:8]=1[S:10]([NH2:13])(=[O:12])=[O:11]참가 물질
5
실험 절차
To a suspension of 5-acetyl-2-aminobenzenesulfonamide (see compound 13) (0.45 g, 2.1 mmol) in 96% EtOH (40 ml) was added H2NOH.HCl (0.28 g, 4 mmol) and 2M NaOH (2 ml). The mixture was boiled for 2 h and the solvent was evaporated. The residue was triturated with water (25 ml) and the product was filtered off and dried, yielding 0.39 g (81%) of 2-amino-5-(1-hydroxyiminoethyl)benzenesulfonamide as yellow powder. The product was further transformed by Method G (using cyclohexanecarboxaldehyde). M.p. 230-233° C.
후처리
- customthe solvent was evaporated
- customThe residue was triturated with water (25 ml)
- filtrationthe product was filtered off
- customdried
출처 및 근거
- ORD 기록
- ord-ad63d2874d654c51b860a80e0dc737e8
- 출처 데이터셋
- uspto-grants-2005_09
- 특허 번호
- US06943159B1
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