Iodine chloride → 2-Amino-5-iodobenzenesulfonamide

HRID 496122노트

반응식

HRID 496122 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:10])=[O:9].[I:12]Cl>C(Cl)(Cl)Cl>[I:12][C:5]1[CH:6]=[CH:7][C:2]([NH2:1])=[C:3]([S:8]([NH2:11])(=[O:9])=[O:10])[CH:4]=1

참가 물질

4

반응물 2

HCID 24640Iodine chlorideHCID 728942-Aminobenzenesulfonamide

생성물 1

HCID 223240882-Amino-5-iodobenzenesulfonamide수율 92%

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

To a cold (0° C.) stirred solution of 2-aminobenzenesulfonamide (17.2 g; 100 mmol) in CHCl3 (200 ml) was added a solution of iodine monochloride (17.1 g; 105 mmol) in CHCl3 (50 ml) over 1 h. The reaction mixture was slowly warmed up to rt. and left with stirring over night. The reaction mixture was filtered and the isolated solid was washed on the filter with CHCl3 (3×20 ml), NaHCO3 (sat. aq., 1×20 ml), H2O (4×50 ml). The isolated solid was air dried to give 27.3 g (92%) of product.

후처리

  1. waitand left
  2. filtrationThe reaction mixture was filtered
  3. washthe isolated solid was washed on the
  4. filtrationfilter with CHCl3 (3×20 ml), NaHCO3 (sat. aq., 1×20 ml), H2O (4×50 ml)
  5. customdried

출처 및 근거

ORD 기록
ord-dcd13d7f0bdc4a148a5865aa46d4f205
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06943159B1

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