Iodine chloride → 5-Iodo-4-methyl-2-aminobenzenesulfonamide
반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[C:4]([NH2:12])[CH:3]=1.[I:13]Cl>C(Cl)(Cl)Cl>[I:13][C:7]1[C:2]([CH3:1])=[CH:3][C:4]([NH2:12])=[C:5]([S:8]([NH2:11])(=[O:9])=[O:10])[CH:6]=1참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
A stirred suspension of 4-methyl-2-aminobenzenesulfonamide (620 mg; 3.3 mmol) in CHCl3 (7 ml) at 0° C. was added a solution of iodine monochloride (1.6 g; 9.9 mmol) in CHCl3 (7 ml). The reaction mixture was stirred at 0° C. until H-NMR indicated full conversion of starting material. The reaction mixture was filtered and the isolated solid washed with small volumes of CHCl3, NaHCO3 (sat. aq.), H2O and air dried to give 640 mg (62%) of product.
후처리
- filtrationThe reaction mixture was filtered
- washthe isolated solid washed with small volumes of CHCl3, NaHCO3 (sat. aq.), H2O and air
- customdried
출처 및 근거
- ORD 기록
- ord-521c5174335347a4bae92bc57db22b50
- 출처 데이터셋
- uspto-grants-2005_09
- 특허 번호
- US06943159B1
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