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Hydrochloric Acid → HCID 73183726, 화합물

HRID 496332
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HRID 496332 반응식
C([O:3][C:4](=[O:29])[CH:5]=[CH:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]2[C:19]([CH3:20])=[C:18]([O:21][CH3:22])[C:17]([O:23][CH3:24])=[C:16]([O:25][CH3:26])[C:15]=2[O:27][CH3:28])=[CH:9][CH:8]=1)C.Cl>[OH-].[Na+].O1CCOCC1>[CH3:28][O:27][C:15]1[C:16]([O:25][CH3:26])=[C:17]([O:23][CH3:24])[C:18]([O:21][CH3:22])=[C:19]([CH3:20])[C:14]=1[CH2:13][C:10]1[CH:11]=[CH:12][C:7]([CH:6]=[CH:5][C:4]([OH:29])=[O:3])=[CH:8][CH:9]=1
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참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 867598433-[4-(2,3,4,5-tetramethoxy-6-methylbenzyl)phenyl]acrylic Acid Ethylester

생성물 1

HCID 73183726HCID 73183726, 화합물수율 96.1%

시약·촉매·용매 2

HCID 14798Sodium Hydroxide용매HCID 312751,4-Dioxane용매

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온도
70 °C

실험 절차

The compound (1.35 g, 3.36 mmol) obtained in Step 4 of Example 1 was dissolved in a mixture of an aqueous solution of 2 N sodium hydroxide (30 ml) and 1,4-dioxane (15 ml), and the mixture was stirred at 70° C. for 3 hours. The reaction mixture was acidified by adding concentrated hydrochloric acid and then was extracted with ethyl acetate. The extract was washed with water, dried, and then the solvent was distilled off to yield the title compound (1.20 g, 3.23 mmol, yield 96%).

후처리

  1. extractionwas extracted with ethyl acetate
  2. washThe extract was washed with water
  3. customdried
  4. distillationthe solvent was distilled off

출처 및 근거

ORD 기록
ord-c1d7eef0eab24a83a2d7cf6801ab536c
출처 데이터셋
uspto-grants-2005_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06943196B1

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