Hydrochloric Acid → (4 Naphth-1-ylpiperid 1-yl)acetonitrile hydrochloride

HRID 4965

반응식

HRID 4965 반응식
Br.[C:2]1([CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:25][C:26]#[N:27].[ClH:28]>CC(C)=O>[ClH:28].[C:2]1([CH:12]2[CH2:17][CH2:16][N:15]([CH2:25][C:26]#[N:27])[CH2:14][CH2:13]2)[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 11534BromoacetonitrileHCID 190962204-(Naphth-1-yl)piperidine hydrobromide

생성물 1

HCID 19784336(4 Naphth-1-ylpiperid 1-yl)acetonitrile hydrochloride수율 91.83%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

5 g of the compound from Example 3, 7.088 g of potassium carbonate and 2.259 g of bromoacetonitrile in 200 ml of acetone are stirred for 10 hours under reflux and a stream of nitrogen. After filtering and evaporation of the filtrate, the residue obtained is treated with an ethanolic solution of hydrogen chloride to give 4.5 g of the expected hydrochloride.

후처리

  1. temperatureunder reflux
  2. filtrationAfter filtering
  3. customevaporation of the filtrate
  4. customthe residue obtained

출처 및 근거

ORD 기록
ord-c23b7acaed9b4fbbb249c32c51607fe4
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05242933

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