Water → 2-Bromo-3-cyclohexyloxy pyridine

HRID 496809

반응식

HRID 496809 반응식
[H-].[Na+].[Br:3][C:4]1[C:9]([OH:10])=[CH:8][CH:7]=[CH:6][N:5]=1.Br[CH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1.O>CN(C)C=O>[Br:3][C:4]1[C:9]([O:10][CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:8][CH:7]=[CH:6][N:5]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 7960Cyclohexyl bromideHCID 230702-Bromo-3-pyridinolHCID 24758Sodium hydride

생성물 1

HCID 223233602-Bromo-3-cyclohexyloxy pyridine수율 30%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

Sodium hydride (160 mg) was dissolved in dimethylformamide (5 ml) and 2-bromo-3-pyridinol (500 mg) dissolved in dimethylformamide is slowly added dropwise. Then, bromocyclohexane (0.7 ml) was added to the solution and reacted for 5 hours at room temperature. Water was added to the suspension to dilute and extracted with ethyl acetate to separate an organic layer. The separated organic layer was dried with anhydrous magnesium sulfate and distilled under reduced pressure. As a result, 2-bromo-3-cyclohexyloxy pyridine (220 mg, yield: 30%) was obtained as an oil phase.

후처리

  1. additionis slowly added dropwise
  2. customreacted for 5 hours at room temperature
  3. additionto dilute
  4. extractionextracted with ethyl acetate
  5. customto separate an organic layer
  6. dry with materialThe separated organic layer was dried with anhydrous magnesium sulfate
  7. distillationdistilled under reduced pressure

출처 및 근거

ORD 기록
ord-048d469ce30545f59c35fb3fe46cfc7d
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06946558B2

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