Pamidronic Acid → Pamidronate Disodium Anhydrous

HRID 49739

반응식

HRID 49739 반응식
[CH2:1]([C:4]([P:10]([OH:13])([OH:12])=[O:11])([P:6]([OH:9])([OH:8])=[O:7])[OH:5])[CH2:2][NH2:3].[OH-].[Na+:15].[OH-].[K+]>>[CH2:1]([C:4]([P:10]([O-:13])([OH:12])=[O:11])([P:6]([O-:8])([OH:9])=[O:7])[OH:5])[CH2:2][NH2:3].[Na+:15].[Na+:15]

참가 물질

4

반응물 3

HCID 4674Pamidronic Acid2회HCID 14797Potassium Hydroxide2회HCID 14798Sodium Hydroxide2회

생성물 1

HCID 73351Pamidronate Disodium Anhydrous

실험 절차

In another embodiment, the invention is directed to a method for preparing a packaged liquid pamidronate alkaline salt composition by (a) combining a sugar with water; (b) combining the mixture of step (a) with pamidronic acid to form a pamidronic acid slurry; (c) adding to the pamidronic acid slurry sufficient aqueous solution of sodium hydroxide or potassium hydroxide to yield a solution having a pH of about 8.5; (d) adding to the resultant solution a pharmaceutically acceptable acid in an amount sufficient to lower the pH of the solution to about 6.5; (e) transferring the solution having a pH of about 6.5 into a vessel having an inner surface which does not react with the solution; and (f) sealing the vessel. Alternatively, a pamidronic acid aqueous slurry can be treated with aqueous sodium hydroxide or potassium hydroxide to form an aqueous solution of pamidronate disodium or pamidronate dipotassium. This solution can then be combined with mannitol and the resulting solution acidified to a pH of about 6.5 with, for example, phosphoric acid.

후처리

  1. customto yield a solution
  2. customdoes not react with the solution

출처 및 근거

ORD 기록
ord-32f9453e79b94d618306116a93a906f4
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06709674B2

연결된 노트

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