Hydrochloric Acid → 3-Cyclobutoxy-phenol
반응식
[CH:1]1([O:5][C:6]2[CH:7]=[C:8]([O:12]C(=O)C)[CH:9]=[CH:10][CH:11]=2)[CH2:4][CH2:3][CH2:2]1.[OH-].[Na+].Cl>CO>[CH:1]1([O:5][C:6]2[CH:7]=[C:8]([OH:12])[CH:9]=[CH:10][CH:11]=2)[CH2:4][CH2:3][CH2:2]1참가 물질
5
실험 절차
Acetic acid 3-cyclobutoxy-phenyl ester (340 mg, 1.65 mmol) was dissolved in methanol (6 ml) and 1 M sodium hydroxide solution (2 ml, 2 mmol) was added. The reaction mixture was stirred at room temperature for 24 hours and then was acidified with 2 M hydrochloric acid. The reaction mixture was extracted with ethyl acetate and the organic solution was dried over magnesium sulphate and concentrated in-vacuo to give 3-cyclobutoxy-phenol (300 mg).
후처리
- extractionThe reaction mixture was extracted with ethyl acetate
- dry with materialthe organic solution was dried over magnesium sulphate
- concentrationconcentrated in-vacuo
출처 및 근거
- ORD 기록
- ord-2d91b7fbfddb4ee4950512002795fb82
- 출처 데이터셋
- uspto-grants-2005_09
- 특허 번호
- US06949573B2
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