Sodium Hydroxide → HCID 178433901, 화합물

HRID 497949노트

반응식

HRID 497949 반응식
[OH:1][C:2]1[C:7]([C:8]([O:10]CC)=[O:9])=[CH:6][N:5]=[C:4]2[N:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)[N:14]=[C:15]([CH3:16])[C:3]=12.[OH-].[Na+]>Cl>[OH:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[CH:6][N:5]=[C:4]2[N:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)[N:14]=[C:15]([CH3:16])[C:3]=12

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 178469580HCID 178469580, 화합물

생성물 1

HCID 178433901HCID 178433901, 화합물수율 33.1%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

반응 조건

온도
100 °C

실험 절차

A suspension of ethyl 4-hydroxy-3-methyl-1-(2-pyridinyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate (2.0 g, 6.7 mmol) in 6N hydrochloric acid solution (10 mL) was heated and stirred at 100° C. for 1 hour. The solution was cooled to room temperature, made weakly acidic by the addition of an aqueous sodium hydroxide solution, and the resulting precipitate was collected by filtration. The crude crystals thus obtained were washed with water and dried to give the title compound (0.6 g, 33% yield).

후처리

  1. temperaturewas heated
  2. temperatureThe solution was cooled to room temperature
  3. filtrationthe resulting precipitate was collected by filtration
  4. customThe crude crystals thus obtained
  5. washwere washed with water
  6. customdried

출처 및 근거

ORD 기록
ord-99b1e2b8f93c4d12ade94fe950e238e3
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06949648B2

반응 노트

불러오는 중…