2,6-Dichloropyridine → 2-Chloro-6-hydrazinopyridine

HRID 497993노트

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HRID 497993 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.O.[NH2:10][NH2:11]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH:10][NH2:11])[N:3]=1

참가 물질

3

반응물 2

HCID 169892,6-DichloropyridineHCID 24654Hydrazine hydrate (1:1)

생성물 1

HCID 3200042-Chloro-6-hydrazinopyridine수율 65.1%

반응 조건

온도
100 °C

실험 절차

The title compound was prepared according to the method described in U.S. Pat. No. 4,260,767 (1981). A mixture of 2,6-dichloropyridine (25.0 g, 169 mmol) and hydrazine monohydrate (60 mL, 1.24 mol) was heated and stirred at 100° C. for 4 hours. The solution was ice cooled, and the resulting crude crystals were collected by filtration. The crystals were washed with cold water and air dried. The crystals thus obtained were recrystallized from chloroform/hexane to give the title compound (15.8 g, 65% yield).

후처리

  1. customThe title compound was prepared
  2. temperaturewas heated
  3. temperaturecooled
  4. filtrationthe resulting crude crystals were collected by filtration
  5. washThe crystals were washed with cold water and air
  6. customdried
  7. customThe crystals thus obtained
  8. customwere recrystallized from chloroform/hexane

출처 및 근거

ORD 기록
ord-86ee93274f1242f89fa1d58b842fc784
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06949648B2

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