4-Chloropyridine → 4-Hydrazinylpyridine hydrochloride

HRID 497996

반응식

HRID 497996 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.O.[NH2:9][NH2:10]>C(O)CC>[ClH:1].[NH:9]([C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1)[NH2:10]

참가 물질

4

반응물 2

HCID 122884-ChloropyridineHCID 24654Hydrazine hydrate (1:1)

생성물 1

HCID 223202584-Hydrazinylpyridine hydrochloride수율 72%

시약·촉매·용매 1

HCID 10311-Propanol용매

반응 조건

온도
0 °C

실험 절차

The title compound was prepared according to the method described in J. Chem. Soc., p. 3830 (1959). A solution of 4-chloropyridine (16.5 g, 145 mmol) and hydrazine monohydrate (7.76 mL, 160 mmol) in 1-propanol (50 mL) was heated under reflux for 18 hours. The solution was cooled to 0° C., and the resulting crystals were collected by filtration. The crystals were washed with cold 1-propanol and air dried to give the title compound (15.2 g, 72% yield). The compound was used in the following process without further purification.

후처리

  1. customThe title compound was prepared
  2. temperatureunder reflux for 18 hours
  3. filtrationthe resulting crystals were collected by filtration
  4. washThe crystals were washed with cold 1-propanol and air
  5. customdried

출처 및 근거

ORD 기록
ord-b6a17618da274f71b76f9270d8a1ace7
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06949648B2

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