홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Hydrochloric Acid → 1-Chloro-4-(4-pyrimidinylmethyl)phthalazine hydrochloride

HRID 49903
노트
인쇄 미리보기

반응식

HRID 49903 반응식
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11](=O)[NH:10][N:9]=2)=[N:3][CH:2]=1.[ClH:19].P(Cl)(Cl)([Cl:22])=O>C(#N)C.O1CCOCC1>[ClH:22].[Cl:19][C:11]1[C:12]2[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]([CH2:7][C:4]2[CH:5]=[CH:6][N:1]=[CH:2][N:3]=2)=[N:9][N:10]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 24813Phosphorus oxychlorideHCID 106813894-(4-pyrimidinylmethyl)-1(2H)-phthalazinone

생성물 1

HCID 227419711-Chloro-4-(4-pyrimidinylmethyl)phthalazine hydrochloride

시약·촉매·용매 2

HCID 6342Acetonitrile용매HCID 312751,4-Dioxane용매

반응 조건

온도
50 °C

실험 절차

850 mg (3.57 mmol) 4-(4-pyrimidinylmethyl)-1(2H)-phthalazinone in 15 ml acetonitrile is mixed with 1.78 ml (7.14 mmol) 4N HCl solution in dioxane and finally with 1.14 ml (12.5 mmol) phosphoryl chloride. After stirring for 36 h at 50° C., the red suspension is filtered and washed with acetonitrile: FAB MS (M−H)+=255. Further product is obtainable from the evaporated filtrate by distribution between dichloromethane and sat. NaHCO3 solution.

후처리

  1. filtrationthe red suspension is filtered
  2. washwashed with acetonitrile

출처 및 근거

ORD 기록
ord-f229d083509946d29a3f7ed6dda7eaaa
출처 데이터셋
uspto-grants-2004_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06710047B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트