3-Hydroxybenzoic Acid → 3-Hydroxy-4-iodobenzoic acid

HRID 49918

반응식

HRID 49918 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6].[I:11]Cl>C(O)(=O)C>[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[I:11])[C:5]([OH:7])=[O:6]

참가 물질

4

반응물 2

HCID 74203-Hydroxybenzoic AcidHCID 24640Iodine chloride

생성물 1

HCID 7368543-Hydroxy-4-iodobenzoic acid

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
45 °C

실험 절차

30.0 g (217 mmol) of 3-hydroxybenzoic acid was dissolved in 200 ml of acetic acid. 53.0 g (326 mmol) of iodine monochloride was added to the obtained solution at room temperature. They were stirred at 45° C. for 15 hours and then the solvent was evaporated under reduced pressure. The residue was washed with 500 ml of 1% aqueous sodium thiosulfate solution twice and with 500 ml of water twice and then dried to solid at 80° C. under reduced pressure to obtain the title compound.

후처리

  1. customthe solvent was evaporated under reduced pressure
  2. washThe residue was washed with 500 ml of 1% aqueous sodium thiosulfate solution twice
  3. dry with materialwith 500 ml of water twice and then dried to solid at 80° C. under reduced pressure

출처 및 근거

ORD 기록
ord-e1eb3d62740b458ea1229145a6525f83
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06710056B2

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