Ethanol → Ethyl 4-(t-Butoxycarbonylamino)-2-hydroxybenzoate

HRID 49943

반응식

HRID 49943 반응식
[C:1]([O:5][C:6]([NH:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([OH:15])=[O:14])=[C:11]([OH:18])[CH:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.CN(C)[CH2:22][CH2:23]CN=C=NCC.C(O)C>CN(C)C1C=CN=CC=1.ClCCl>[C:1]([O:5][C:6]([NH:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([O:15][CH2:22][CH3:23])=[O:14])=[C:11]([OH:18])[CH:10]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

6

반응물 3

HCID 702EthanolHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 103324764-(((Tert-butoxy)carbonyl)amino)-2-hydroxybenzoic acid

생성물 1

HCID 17834349Ethyl 4-(t-Butoxycarbonylamino)-2-hydroxybenzoate

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매2회

실험 절차

A mixture of 1.2 g of 4-(t-butoxycarbonylamino)-2-hydroxybenzoic acid, 900 mg of 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (WSC·HCl), 550 mg of 4-dimethylaminopyridine, 1 ml of ethanol and 30 ml of dichloromethane was stirred at room temperature. The reaction mixture was treated with dichloromethane as the extracting solvent in an ordinary manner and then purified by the silica gel chromatography (ethyl acetate/hexane) to obtain the title compound.

후처리

  1. custompurified by the silica gel chromatography (ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-6ad0c6b22fd34371956974c9cbee2ff2
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06710056B2

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