Hydrochloric Acid → 2-Fluoro-5-(trifluoromethyl)aniline
반응식
[N+:1]([C:4]1[CH:5]=[C:6]([C:11]([F:14])([F:13])[F:12])[CH:7]=[CH:8][C:9]=1[F:10])([O-])=O.Cl.C(=O)(O)[O-].[Na+].C(OCC)C>CO.[Fe]>[F:10][C:9]1[CH:8]=[CH:7][C:6]([C:11]([F:12])([F:13])[F:14])=[CH:5][C:4]=1[NH2:1]참가 물질
7
실험 절차
Twenty grams of 3-nitro-4-fluorobenzotrifluoride was dissolved in 50 ml of methanol. An iron powder (16 g) was added and concentrated hydrochloric acid was added dropwise with stirring. The reaction mixture was stirred overnight, followed by addition of sodium bicarbonate for neutralization. Then diethyl ether was added, and the insolubles were filtered off with cerite. The ether phase was separated, dried and concentrated under reduced pressure, giving 14 g of the contemplated product (yield 82%).
후처리
- stirringThe reaction mixture was stirred overnight
- filtrationthe insolubles were filtered off with cerite
- customThe ether phase was separated
- customdried
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-67f0e5b6c7a5411682cf7addfc7c992c
- 출처 데이터셋
- uspto-grants-2004_03
- 특허 번호
- US06710062B1
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