1,4-Butane sultone → 2,3-Dimethyl-1,3-bis(4-sulfobutyl)-5-sulfo-3H-indole

HRID 500099

반응식

HRID 500099 반응식
[CH3:1][C:2]1[C:10]([CH3:19])([CH2:11][CH2:12][CH2:13][CH2:14][S:15]([OH:18])(=[O:17])=[O:16])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([S:20]([OH:23])(=[O:22])=[O:21])[CH:8]=2)[N:3]=1.[CH2:24]1[S:29](=[O:31])(=[O:30])[O:28][CH2:27][CH2:26][CH2:25]1.S1(CCCC1)(=O)=O>C(OCC)C>[CH3:1][CH:2]1[C:10]([CH3:19])([CH2:11][CH2:12][CH2:13][CH2:14][S:15]([OH:18])(=[O:16])=[O:17])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([S:20]([OH:23])(=[O:21])=[O:22])[CH:8]=2)[N:3]1[CH2:27][CH2:26][CH2:25][CH2:24][S:29]([OH:31])(=[O:30])=[O:28]

참가 물질

5

반응물 3

HCID 154111,4-Butane sultoneHCID 31347SulfolaneHCID 593662262,3-Dimethyl-3-(4-sulfobutyl)-3H-indole-5-sulfonic acid

생성물 1

HCID 866461922,3-Dimethyl-1,3-bis(4-sulfobutyl)-5-sulfo-3H-indole수율 86.8%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
140 °C

실험 절차

To 2,3-dimethyl-3-(4-sulfobutyl)-5-sulfo-3H-indole (10 g) was added butane sultone (30 g) and the mixture heated to 140° C. overnight. On cooling to room temperature, sulfolan (20 ml) was added and the mixture poured into diethyl ether (500 ml). The resultant precipitate was removed by filtration and dried to give the desired product (12 g).

후처리

  1. temperatureOn cooling to room temperature
  2. customThe resultant precipitate was removed by filtration
  3. customdried

출처 및 근거

ORD 기록
ord-967fe06e8ce64cbea94cfa6f6fa5c726
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07767829B2

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