Hydrogen Bromide → Methyl 2-fluoro-4-(oxoacetyl)benzoate

HRID 500135노트

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HRID 500135 반응식
[C:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[C:6]([F:14])[CH:5]=1)(=[O:3])[CH3:2].Br.[OH2:16]>CS(C)=O>[F:14][C:6]1[CH:5]=[C:4]([C:1](=[O:3])[CH:2]=[O:16])[CH:13]=[CH:12][C:7]=1[C:8]([O:10][CH3:11])=[O:9]

참가 물질

5

반응물 3

HCID 260Hydrogen BromideHCID 962WaterHCID 59216348Methyl 4-acetyl-2-fluorobenzoate

생성물 1

HCID 59216303Methyl 2-fluoro-4-(oxoacetyl)benzoate

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

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온도
60 °C

실험 절차

A mixture of methyl 4-acetyl-2-fluorobenzoate (1.6 g, 8.2 mmol) and 8.8M hydrogen bromide in water (2.8 mL) in dimethyl sulfoxide (20 mL) was stirred at 60° C. overnight. After cooling, the mixture was poured into ice-water. The reaction mixture was extracted with diethyl ether. The combined organic extracts were washed with brine, dried over sodium sulfate, filtered and concentrated to yield the desired product which was used in the next reaction step without further purification. (1.60 g, 93.3%).

후처리

  1. temperatureAfter cooling
  2. extractionThe reaction mixture was extracted with diethyl ether
  3. washThe combined organic extracts were washed with brine
  4. dry with materialdried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a87039acc3804dbfb58fc9e9b663e4e3
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07767675B2

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