Hydrochloric Acid → 5-Chloro-3-(3,5-dimethylphenylsulfonyl)indole-2-carboxylic acid

HRID 50035노트

반응식

HRID 50035 반응식
[OH2:1].[OH-:2].[Li+].[Cl:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9]([C:14]([O:16]C)=[O:15])=[C:8]2[S:18][C:19]1[CH:24]=[C:23]([CH3:25])[CH:22]=[C:21]([CH3:26])[CH:20]=1.Cl>O1CCCC1.O>[Cl:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9]([C:14]([OH:16])=[O:15])=[C:8]2[S:18]([C:19]1[CH:24]=[C:23]([CH3:25])[CH:22]=[C:21]([CH3:26])[CH:20]=1)(=[O:2])=[O:1]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 11727682Methyl 5-chloro-3-(3,5-dimethylphenylthio)indole-2-carboxylate

생성물 1

HCID 113719555-Chloro-3-(3,5-dimethylphenylsulfonyl)indole-2-carboxylic acid

시약·촉매·용매 2

HCID 962Water용매2회HCID 8028Tetrahydrofuran용매

실험 절차

Lithium hydroxide monohydrate (0.33 g, 0.0079 mol) was added to a solution of methyl 5-chloro-3-(3,5-dimethylphenylthio)indole-2-carboxylate (1.0 g, 0.0026 mol) in tetrahydrofuran (30 mL) and water (30 mL), then reaction was stirred at room temperature for 4 days. After dilution with water the mixture was acidified with 1N HCl and extracted with ethyl acetate. Organic reaction was washed with brine and dried. Evaporation of the solvent furnished 0.94 (100%) of title compound, mp 277-278° C. (from ethanol).

후처리

  1. customreaction
  2. extractionextracted with ethyl acetate
  3. customOrganic reaction
  4. washwas washed with brine
  5. customdried
  6. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-151f78a6f9304158948cef2c4903e3d9
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06710068B2

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