Azobisisobutyronitrile → Methyl 2-(bromomethyl)benzoate
반응식
[CH3:1][O:2][C:3](=[O:11])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH3:10].[Br:12]N1C(=O)CCC1=O.CC(N=NC(C#N)(C)C)(C#N)C>ClC(Cl)(Cl)Cl>[CH3:1][O:2][C:3](=[O:11])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][Br:12]참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
To a solution of 2-methylbenzoic acid methyl ester (33.0 g) in tetrachlorocarbon (440 ml) were added N-bromosuccinimide (43.0 g) and AIBN (2,2′-azobisisobutyronitrile, 361 mg) and the mixture was refluxed for 30 minutes. The reaction mixture was cooled down to 0° C. and cinnamoic acid that appeared were filtered off and the filtrate was concentrated. The residue was purified by distillation under reduced pressure to give the title compound having the following physical data (28.0 g, colorless oil).
후처리
- temperaturethe mixture was refluxed for 30 minutes
- filtrationcinnamoic acid that appeared were filtered off
- concentrationthe filtrate was concentrated
- distillationThe residue was purified by distillation under reduced pressure
출처 및 근거
- ORD 기록
- ord-a96861900862401e895e29ef678b6cde
- 출처 데이터셋
- uspto-grants-2004_03
- 특허 번호
- US06710205B2
반응 노트
불러오는 중…