반응식
[CH3:1][C:2]1[CH:10]=[C:9]([C:11]([NH:13][CH:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[O:12])[CH:8]=[C:7]([CH3:20])[C:3]=1[C:4]([OH:6])=[O:5].C(OC(N1CCC(NC(=O)[C:36]2[CH:41]=[C:40](C)[C:39]([C:43](OC(C)(C)C)=O)=[C:38](C)[CH:37]=2)CC1)=O)(C)(C)C.FC(F)(F)C(O)=O.[CH:59]([O:62]C1C=C(C=C(OC(C)C)C=1)C=O)([CH3:61])[CH3:60].[OH:75][C:76]1[CH:77]=C(C=C(O)[CH:83]=1)C=O.BrC(C)C.C(=O)([O-])[O-].[K+].[K+].C([BH3-])#N.[Na+].C(N(C(C)C)C(C)C)C>ClCCl.CN(C=O)C.C(O)C.C(O)(=O)C>[CH:59]([O:62][C:41]1[CH:40]=[C:39]([CH:38]=[C:37]([O:75][CH:76]([CH3:77])[CH3:83])[CH:36]=1)[CH2:43][N:17]1[CH2:16][CH2:15][CH:14]([NH:13][C:11](=[O:12])[C:9]2[CH:10]=[C:2]([CH3:1])[C:3]([C:4]([OH:6])=[O:5])=[C:7]([CH3:20])[CH:8]=2)[CH2:19][CH2:18]1)([CH3:61])[CH3:60]참가 물질
14
반응물 9
HCID 63582-Bromopropane
HCID 6422Trifluoroacetic acid
HCID 11430Potassium Carbonate
HCID 81531Diisopropylethylamine
HCID 943653,5-Dihydroxybenzaldehyde
HCID 5003444Sodium cyanoborohydride
HCID 113106053,5-diisopropoxybenzaldehyde
HCID 68456914HCID 68456914, 화합물
HCID 684591004-(4-Tert-butoxycarbonyl-3,5-dimethyl-benzoylamino)-piperidine-1-carboxylic acid tert-butyl ester생성물 1
시약·촉매·용매 4
실험 절차
In analogy to the procedure described in example 50k), 2,6-dimethyl-N-piperidin-4-yl-terephthalamic acid [prepared from 4-(4-tert-butoxycarbonyl-3,5-dimethyl-benzoylamino)-piperidine-1-carboxylic acid tert-butyl ester and trifluoroacetic acid in dichloromethane in analogy to the procedure described in example 50i)] was reacted with 3,5-diisopropoxy-benzaldehyde [prepared from 3,5-dihydroxy-benzaldehyde and 2-bromopropane, potassium carbonate in DMF at 60° C. in analogy to the procedure described in example 50e)], sodium cyanoborohydride, N-ethyl-diisopropylamine and acetic acid in ethanol at 50° C. to yield the title compound as light yellow solid. MS: 483.3 (MH+).
후처리
- customat 50° C.
출처 및 근거
- ORD 기록
- ord-ab22671dc0ac441f929df473d29d604d
- 출처 데이터셋
- uspto-grants-2010_08
- 특허 번호
- US07772253B2
연결된 노트
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