Hydrochloric Acid → 6-(Dimethylamino)-5-methyl-3-pyridinecarboxylic acid

반응식

[CH3:1][N:2]([CH3:12])[C:3]1[C:10]([CH3:11])=[CH:9]C(C#N)=[CH:5][N:4]=1.[OH-].[Na+].Cl.C1C[O:19]CC1.[CH2:21]([OH:23])[CH3:22]>>[CH3:1][N:2]([CH3:12])[C:3]1[C:10]([CH3:11])=[CH:9][C:22]([C:21]([OH:19])=[O:23])=[CH:5][N:4]=1

참가 물질

반응물 4

HCID 313Hydrochloric Acid

HCID 14798Sodium Hydroxide

HCID 21873804Tetrahydrofuran ethanol

HCID 68455945HCID 68455945, 화합물

생성물 1

HCID 684549596-(Dimethylamino)-5-methyl-3-pyridinecarboxylic acid

실험 절차

The above prepared 6-dimethylamino-5-methyl-nicotinonitrile (0.435 g, 2.70 mmol) was dissolved in 13.6 ml of THF/ethanol=1/1 and treated with 6.75 ml of 2N NaOH (5 eq.). The mixture was refluxed for 30 h; aliquots were taken from time to time and analyzed by MS to follow the disappearance of the amide intermediate. After cooling down to room temperature, the pH was adjusted with HCl to 3. Careful evaporation of the solvents and drying under HV left 1.45 g of the title acid as white solid, contaminated with NaCl, which was used as such for the next step.