Benzylamine → N-[(Trimethylsilyl)methyl]benzylamine

HRID 504390

반응식

HRID 504390 반응식
Cl[CH2:2][Si:3]([CH3:6])([CH3:5])[CH3:4].[CH2:7]([NH2:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[OH-].[Na+]>>[CH2:7]([NH:14][CH2:2][Si:3]([CH3:6])([CH3:5])[CH3:4])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

4

반응물 3

HCID 7504BenzylamineHCID 14798Sodium HydroxideHCID 75361Silane, (chloromethyl)trimethyl-

생성물 1

HCID 353458N-[(Trimethylsilyl)methyl]benzylamine

반응 조건

온도
200 °C

실험 절차

Into a round bottom 3-neck flask equipped with a nitrogen flow, a magnetic stirrer, and a friedrichs condenser was added (chloromethyl)trimethylsilane (0.100 mol). To the flask was added benzylamine (0.300 mol), with stirring, and the resulting solution heated at 200° C. for 2.5 hours. Sodium hydroxide aqueous solution (0.1N) was added in order to hydrolyze the white organic salt that had formed. The mixture was extracted with ether and the ether layer was dried over magnesium sulfate and concentrated under reduced pressure through a Vigreux column to give the product at b.p. 68-72° C./0.7-0.8 mm.

후처리

  1. customInto a round bottom 3-neck flask equipped with a nitrogen flow, a magnetic stirrer, and a friedrichs condenser
  2. customhad formed
  3. extractionThe mixture was extracted with ether
  4. dry with materialthe ether layer was dried over magnesium sulfate
  5. concentrationconcentrated under reduced pressure through a Vigreux column
  6. customto give the product at b.p. 68-72° C./0.7-0.8 mm

출처 및 근거

ORD 기록
ord-7ad37f2ee00d4b24a80da9b4ab46cdd9
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07776874B2

연결된 노트

불러오는 중…