Hydrochloric Acid → 4-Hydrazinyl-2-(methoxymethyl)benzonitrile hydrochloride

HRID 505697노트

반응식

HRID 505697 반응식
F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([CH2:10][O:11][CH3:12])[CH:3]=1.O.[NH2:14][NH2:15].C(O)C.[ClH:19]>CO.C(OCC)C>[ClH:19].[NH:14]([C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([CH2:10][O:11][CH3:12])[CH:3]=1)[NH2:15]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 594293094-Fluoro-2-(methoxymethyl)benzonitrile

생성물 1

HCID 469151914-Hydrazinyl-2-(methoxymethyl)benzonitrile hydrochloride

시약·촉매·용매 2

HCID 887Methanol용매HCID 3283Diethyl Ether용매

실험 절차

A mixture of 4-fluoro-2-(methoxymethyl)benzonitrile (110 mg, 0.67 mmol), hydrazine monohydrate (133 mg, 0.13 mL, 2.6 mmol) and ethanol (5 mL) was heated to reflux overnight. The mixture was cooled to room temp and condensed. The residue was dissolved in methanol and treated with 2.0 N Hydrogen chloride in diethyl ether. The solvent was removed and the solid was dried to give 4-hydrazinyl-2-(methoxymethyl)benzonitrile hydrochloride as an off-white solid.

후처리

  1. temperaturewas heated
  2. temperatureto reflux overnight
  3. customcondensed
  4. customThe solvent was removed
  5. customthe solid was dried

출처 및 근거

ORD 기록
ord-6b1498ae6dcc4bf6858cdda7915a81dd
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07781428B2

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