Water → HCID 178423844, 화합물

HRID 506433노트

반응식

HRID 506433 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][C:10]([O:12]C)=[O:11])=[CH:4][CH:3]=1.Cl.[NH2:16]O.[OH-].[Na+].O>CO>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([OH:12])[O:11][N:16]=2)=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 291780Methyl 3-(4-methylphenyl)-3-oxopropanoateHCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 178423844HCID 178423844, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

According to method of U.S. Pat. No. 3,781,438, 2 g of methyl 3-(4-methylphenyl)-3-oxopropanoate was dissolved in methanol, slightly excessive hydroxylamine hydrochloride and equivalent amount of sodium hydroxide were added, the mixture was heated to reflux. 3 hr later, the reaction was traced by Thin-Layer Chromatography, after the reaction, water was added to the reaction mixture, extracted with ethyl acetate, The combined organic extracts were dried and concentrated to obtain 3-(4-methylphenyl)isoxazol-5-ol as solid (compound III-3).

후처리

  1. temperaturethe mixture was heated to reflux
  2. custom3 hr
  3. additionwas added to the reaction mixture
  4. extractionextracted with ethyl acetate
  5. customThe combined organic extracts were dried
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-6372c26c00e94c609b4d3a29f03f5a7b
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07786045B2

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