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Acetic Anhydride → (S)-4-(((3-Fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)methyl)carbamoyl)-2-nitrophenyl Acetate

HRID 509416
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HRID 509416 반응식
[F:1][C:2]1[C:3]([C@H:8]([C:22]2[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=2)[NH:9][C:10](=[O:21])[C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[C:13]([N+:18]([O-:20])=[O:19])[CH:12]=2)=[N:4][CH:5]=[CH:6][CH:7]=1.[C:32](OC(=O)C)(=[O:34])[CH3:33].CCN(C(C)C)C(C)C>C(Cl)Cl>[C:32]([O:17][C:14]1[CH:15]=[CH:16][C:11]([C:10](=[O:21])[NH:9][C@H:8]([C:3]2[C:2]([F:1])=[CH:7][CH:6]=[CH:5][N:4]=2)[C:22]2[CH:27]=[CH:26][C:25]([C:28]([F:30])([F:31])[F:29])=[CH:24][CH:23]=2)=[CH:12][C:13]=1[N+:18]([O-:20])=[O:19])(=[O:34])[CH3:33]
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참가 물질

5

반응물 3

HCID 7918Acetic AnhydrideHCID 81531DiisopropylethylamineHCID 71144294(S)-N-((3-Fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)methyl)-4-hydroxy-3-nitrobenzamide

생성물 1

HCID 86687996(S)-4-(((3-Fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)methyl)carbamoyl)-2-nitrophenyl Acetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (S)—N-((3-fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)methyl)-4-hydroxy-3-nitrobenzamide (83 mg, 0.191 mmol) and DCM (5 mL) were added acetic anhydride (0.2 mL, 2.120 mmol) and DIPEA (0.15 mL, 0.861 mmol). After stirring for 45 min, the reaction was quenched with water and after stirring for 3 days, the aqueous solution was filtered to give the title compound as a yellow solid. The resulting product was used in the next step without further purification. MS (ESI pos. ion) m/z: 478.1 (M+H).

후처리

  1. customthe reaction was quenched with water
  2. stirringafter stirring for 3 days
  3. filtrationthe aqueous solution was filtered

출처 및 근거

ORD 기록
ord-1ea1db74854d462998aaa631bb322b8c
출처 데이터셋
uspto-grants-2015_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09096527B2

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