Hydrochloric Acid → ({[(3-Methylbutyl)amino]methyl}cyclopentyl)methan-1-ol

HRID 51064노트

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HRID 51064 반응식
[CH3:1][CH:2]([CH3:17])[CH2:3][CH2:4][NH:5][C:6]([C:8]1([C:13](OC)=[O:14])[CH2:12][CH2:11][CH2:10][CH2:9]1)=O.Cl.[OH-].[Na+]>C1COCC1.O>[CH3:1][CH:2]([CH3:17])[CH2:3][CH2:4][NH:5][CH2:6][C:8]1([CH2:13][OH:14])[CH2:9][CH2:10][CH2:11][CH2:12]1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22135199HCID 22135199, 화합물

생성물 1

HCID 22736527({[(3-Methylbutyl)amino]methyl}cyclopentyl)methan-1-ol

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
75 °C

실험 절차

To a solution of methyl 1-[N-(3-methylbutyl)-carbamoyl]-cyclopentanecarboxylate (900 mg, 3.7 mmol) in THF at rt was added BH3/THF complex ) 7.4 mL, 7.4 mmol) and stirred at 75° C. for 5 hours. To this reaction mixture was added 6N HCl (10 mL) and the mixture was further stirred for 30 min before the solution was neutralized by 1N NaOH. The solution was diluted with water and extracted with EtOAc. The combined extracts were dried over magnesium sulfate, and concentrated to a crude oil (700 mg, 95%). MS [M+H]+200.

후처리

  1. stirringthe mixture was further stirred for 30 min before the solution
  2. extractionextracted with EtOAc
  3. dry with materialThe combined extracts were dried over magnesium sulfate
  4. concentrationconcentrated to a crude oil (700 mg, 95%)

출처 및 근거

ORD 기록
ord-a5c29a430b75420d8359c63d0415a4dd
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06713476B2

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