Formaldehyde → (2S)-2-(4-Methoxybenzylthiomethyl)-1-methylpyrrolidine

HRID 5108

반응식

HRID 5108 반응식
[CH3:1][O:2][C:3]1[CH:16]=[CH:15][C:6]([CH2:7][S:8][CH2:9][C@@H:10]2[CH2:14][CH2:13][CH2:12][NH:11]2)=[CH:5][CH:4]=1.C=O.[C:19]([BH3-])#N.[Na+]>C(#N)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][S:8][CH2:9][C@@H:10]2[CH2:14][CH2:13][CH2:12][N:11]2[CH3:19])=[CH:15][CH:16]=1

참가 물질

5

반응물 3

HCID 712FormaldehydeHCID 5003444Sodium cyanoborohydrideHCID 57043207(2S)-2-(4-methoxybenzylthiomethyl)pyrrolidine

생성물 1

HCID 57048351(2S)-2-(4-Methoxybenzylthiomethyl)-1-methylpyrrolidine수율 41.7%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

The procedure described in Preparation 5-(4) was repeated, but using 2 g of (2S)-2-(4-methoxybenzylthiomethyl)pyrrolidine, 35% formalin and 848 mg of sodium cyanoborohydride in the presence of 44 ml of acetonitrile, to afford 883 mg of the title compound as an oil.

후처리

  1. customThe procedure described in Preparation 5-(4)

출처 및 근거

ORD 기록
ord-1fc826cd6595419badb8308649438ba2
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05242914

연결된 노트

불러오는 중…