Triethylamine → Ethyl 3-(1-ethyl-3-pyrrolecarboxamido)propionate

HRID 51234

반응식

HRID 51234 반응식
[CH2:1]([N:3]1[CH:7]=[CH:6][C:5]([C:8]([OH:10])=O)=[CH:4]1)[CH3:2].Cl.[CH2:12]([O:14][C:15](=[O:19])[CH2:16][CH2:17][NH2:18])[CH3:13].Cl.C(N=C=NCCCN(C)C)C.C(N(CC)CC)C>C(Cl)Cl>[CH2:1]([N:3]1[CH:7]=[CH:6][C:5]([C:8]([NH:18][CH2:17][CH2:16][C:15]([O:14][CH2:12][CH3:13])=[O:19])=[O:10])=[CH:4]1)[CH3:2]

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 458475beta-Alanine, ethyl ester, hydrochlorideHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 227379231-Ethyl-1H-pyrrole-3-carboxylic acid

생성물 1

HCID 12146426Ethyl 3-(1-ethyl-3-pyrrolecarboxamido)propionate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Into a suspension of 3.33 g (23.9 mmol) of 1-ethyl-3-pyrrolecarboxylic acid, 4.41 g (28.7 mmol) of β-alanine ethyl ester hydrochloride and 5.50 g (28.7 mmol) of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride in 40 ml of methylene chloride, 4.0 ml (28.7 mmol) of triethylamine were added dropwise under ice cooling and stirring. The reaction mixture was stirred at room temperature for 2.5 hours.

후처리

  1. additionwere added dropwise under ice cooling
  2. stirringThe reaction mixture was stirred at room temperature for 2.5 hours

출처 및 근거

ORD 기록
ord-bcbd69472e4d41af916ac052054b1c80
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06713634B2

연결된 노트

불러오는 중…