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Diisopropylethylamine → 6-Chloro-4-(1-phenylcyclopropylamino)nicotinamide

HRID 513272
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인쇄 미리보기

반응식

HRID 513272 반응식
Cl[C:2]1[C:7]([C:8]([NH2:10])=[O:9])=[CH:6][N:5]=[C:4]([Cl:11])[CH:3]=1.[C:12]1([C:18]2([NH2:21])[CH2:20][CH2:19]2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.CCN(C(C)C)C(C)C>C(C#N)(C)=O>[Cl:11][C:4]1[CH:3]=[C:2]([NH:21][C:18]2([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH2:20][CH2:19]2)[C:7]([C:8]([NH2:10])=[O:9])=[CH:6][N:5]=1
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참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 1945491-Phenyl-cyclopropylamineHCID 6000444,6-Dichloronicotinamide

생성물 1

HCID 866645416-Chloro-4-(1-phenylcyclopropylamino)nicotinamide수율 36.5%

시약·촉매·용매 1

HCID 694302-Oxopropiononitrile용매

반응 조건

온도
60 °C

실험 절차

To a suspension of 4,6-dichloronicotinamide (191 mg, 1 mmol) in AcCN (2 mL) was added 1-phenylcyclopropanamine (160 mg, 1.2 mmol) and DIPEA (0.213 mL, 1.2 mmol). The mixture was heated at 60° C. for 2 days. The mixture was concentrated and purified by column chromatography to give 6-chloro-4-(1-phenylcyclopropylamino)nicotinamide (105 mg).

후처리

  1. concentrationThe mixture was concentrated
  2. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-bf1fb13d2bfd4e1ab3635b34fda50fdf
출처 데이터셋
uspto-grants-2015_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09102625B2

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