1-Fluoro-3-nitrobenzene → Tert-butyl 4-(3-nitrophenyl)piperazine-1-carboxylate

HRID 513283

반응식

HRID 513283 반응식
F[C:2]1[CH:3]=[C:4]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[C:11]([N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1)([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12]>CS(C)=O>[N+:8]([C:4]1[CH:3]=[C:2]([N:21]2[CH2:20][CH2:19][N:18]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:23][CH2:22]2)[CH:7]=[CH:6][CH:5]=1)([O-:10])=[O:9]

참가 물질

4

반응물 2

HCID 98231-Fluoro-3-nitrobenzeneHCID 143452tert-Butyl piperazine-1-carboxylate

생성물 1

HCID 22330126Tert-butyl 4-(3-nitrophenyl)piperazine-1-carboxylate수율 33.1%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

반응 조건

온도
100 °C

실험 절차

To a solution of 3-fluoronitrobenzene (2 mL, 18.8 mmol) in DMSO (20 mL) was added Boc-piperazine (10 g, 56.4 mmol), after stirring at 100° C. for 3 days, the mixture was poured to ice water, the resulting precipitate was collected by filtration to give tert-butyl 4-(3-nitrophenyl)piperazine-1-carboxylate (1.91 g).

후처리

  1. filtrationthe resulting precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-3970f499b7be4a94a6d0505339b2eead
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102625B2

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