Hydrazine hydrate (1:1) → 2-Chloroquinolin-8-amine

HRID 513380노트

반응식

HRID 513380 반응식
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[C:5]([N+:12]([O-])=O)[CH:6]=[CH:7][CH:8]=2)[N:3]=1.O.NN>[Ni].CO>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[C:5]([NH2:12])[CH:6]=[CH:7][CH:8]=2)[N:3]=1

참가 물질

5

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 3194532-Chloro-8-nitroquinoline2회

생성물 1

HCID 3465192-Chloroquinolin-8-amine수율 82%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

In the similar fashion using route 6 general procedure 14, 2-chloro-8-nitroquinoline (Intermediate 24) (100 mg, 0.48 mmol), Raney nickel (20 mg, 20% wt), hydrazine hydrate (96 mg, 1.92 mmol) and MeOH (10 ml) gave the crude title compound (70 mg, 82%) which was used in the next step without purification.

출처 및 근거

ORD 기록
ord-71d4cc4850ba47518f19eedc5e69d5a4
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102688B2

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