Stannous Chloride → 5-Fluoroquinolin-8-amine

HRID 513402노트

반응식

HRID 513402 반응식
[F:1][C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.[Sn](Cl)Cl>Cl>[F:1][C:2]1[CH:11]=[CH:10][C:9]([NH2:12])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2

참가 물질

4

반응물 2

HCID 24479Stannous ChlorideHCID 1539725-Fluoro-8-nitroquinoline2회

생성물 1

HCID 445582645-Fluoroquinolin-8-amine수율 106.7%

시약·촉매·용매 1

HCID 313Hydrochloric Acid촉매

실험 절차

In a similar fashion using route 1 general procedure 4, 5-fluoro-8-nitroquinoline (Intermediate 38) (500 mg, 2.60 mmol), tin (II) chloride (1.48 mg, 7.80 mmol) and 6N HCl (4 drops) gave the title compound (450 mg, >100% crude) which was used in the next step without purification. The structure was confirmed by 1H NMR.

출처 및 근거

ORD 기록
ord-298ae85fea2e40198d3e3363f146e7b2
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102688B2

반응 노트

불러오는 중…