Benzenesulfonyl chloride → N-(2-methylquinolin-8-yl)benzenesulfonamide

HRID 513466노트

반응식

HRID 513466 반응식
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[C:5]([NH2:12])[CH:6]=[CH:7][CH:8]=2)[N:3]=1.[C:13]1([S:19](Cl)(=[O:21])=[O:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>CN(C1C=CN=CC=1)C>[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[C:5]([NH:12][S:19]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)(=[O:21])=[O:20])[CH:6]=[CH:7][CH:8]=2)[N:3]=1

참가 물질

4

반응물 2

HCID 7369Benzenesulfonyl chlorideHCID 1404572-Methyl-8-aminoquinoline2회

생성물 1

HCID 2848041N-(2-methylquinolin-8-yl)benzenesulfonamide수율 43%

시약·촉매·용매 1

HCID 142844-(Dimethylamino)pyridine촉매

실험 절차

In the similar fashion using route 14 general procedure 27, 2-methyl-8-aminoquinoline (Intermediate 22) (200 mg, 1.2 mmol), benzenesulfonyl chloride (230 mg, 1.2 mmol) and DMAP (cat.) gave the title compound (150 mg, 43%) after purification by column chromatography with DCM as the eluent.

출처 및 근거

ORD 기록
ord-e2a79950bf3740699f7a9a2b8d9a89f0
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102688B2

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