Stannous Chloride → 2-Amino-4-methoxy-N-(2-methyl-quinolin-8-yl)-benzenesulfonamide

HRID 513552노트

반응식

HRID 513552 반응식
[N+:1]([C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[S:12]([NH:15][C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[C:25]=1[N:24]=[C:23]([CH3:26])[CH:22]=[CH:21]2)(=[O:14])=[O:13])([O-])=O.[Sn](Cl)Cl>Cl>[NH2:1][C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[S:12]([NH:15][C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[C:25]=1[N:24]=[C:23]([CH3:26])[CH:22]=[CH:21]2)(=[O:14])=[O:13]

참가 물질

4

반응물 2

HCID 24479Stannous ChlorideHCID 236319492-Nitro-4-methoxy-N-(2-methyl-quinolin-8-yl)-benzenesulfonamide2회

생성물 1

HCID 167599482-Amino-4-methoxy-N-(2-methyl-quinolin-8-yl)-benzenesulfonamide수율 72.8%

시약·촉매·용매 1

HCID 313Hydrochloric Acid촉매

실험 절차

In the similar fashion using route 1 general procedure 4, 2-nitro-4-methoxy-N-(2-methyl-quinolin-8-yl)-benzenesulfonamide (Intermediate 150) (550 mg, 1.4 mmol), tin (II) chloride (838 mg, 4.4 mmol) and 6N HCl (2 drops) gave the title compound (350 mg, 70%).

출처 및 근거

ORD 기록
ord-5dd526d5e3644a9fa774717be4640a27
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102688B2

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