Stannous Chloride → 8-Quinolinamine, 4-(trifluoromethyl)-
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[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[N:12]=[CH:11][CH:10]=[C:9]2[C:14]([F:17])([F:16])[F:15])([O-])=O.Cl[Sn]Cl>Cl.CCO>[F:17][C:14]([F:15])([F:16])[C:9]1[C:8]2[C:13](=[C:4]([NH2:1])[CH:5]=[CH:6][CH:7]=2)[N:12]=[CH:11][CH:10]=1참가 물질
5
실험 절차
In a similar fashion using route 2 general procedure 4, 8-nitro-4-trifluoromethyl-quinoline 468 (900 mg, 4.13 mmol), SnCl2 (3.12 g, 16.5 mmol), 6N HCl (2 drops) and EtOH (20 ml) at 85° C. for 3 h gave the title compound (700 mg, 89%) which was used in the next step without further purification.
후처리
- customat 85° C.
- customfor 3 h
출처 및 근거
- ORD 기록
- ord-3bc4b273e9c84307acfff241f4a43ef5
- 출처 데이터셋
- uspto-grants-2015_08
- 특허 번호
- US09102688B2
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