Cyclohexanone → 1-Cyclohexylpyrrolidine

HRID 514644

반응식

HRID 514644 반응식
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:6]1(=O)[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1.[O-]S([O-])(=O)=O.[Mg+2]>C1CCCCC1>[CH:6]1([N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1

참가 물질

5

반응물 3

HCID 7967Cyclohexanone2회HCID 24083Sulfuric acid magnesium salt (1:1)HCID 31268Pyrrolidine

생성물 1

HCID 1390641-Cyclohexylpyrrolidine수율 91%

시약·촉매·용매 1

HCID 8078Cyclohexane용매

실험 절차

Cyclohexylpyrrolidine was prepared as described in the procedure below illustrated in Scheme 1. In a 3-neck reaction flask equipped with a mechanical stirrer and heating mantle, a 2 molar equivalent of pyrrolidine were mixed with 1 molar equivalent of cyclohexanone in dry cyclohexane to make a 1M solution with respect to the cyclohexanone. To the mixture, 2 molar equivalents of anhydrous MgSO4 (as dehydrating agent) were added. The resulting mixture was refluxed for 94 hours. The progress of the reaction was monitored by NMR analysis.

후처리

  1. customIn a 3-neck reaction flask equipped with a mechanical stirrer
  2. temperatureheating mantle
  3. temperatureThe resulting mixture was refluxed for 94 hours

출처 및 근거

ORD 기록
ord-b7724158c78141338e8d3ee33dce76d4
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09108856B2

연결된 노트

불러오는 중…