Formic Acid → HCID 178479550, 화합물

HRID 514672

반응식

HRID 514672 반응식
[NH2:1][CH:2]([C:6]([NH2:8])=[O:7])[C:3]([NH2:5])=[O:4].[CH:9](O)=[O:10].C(OCC)(OCC)OCC.[ClH:22]>O.CC(O)C>[OH2:4].[OH2:10].[ClH:22].[OH:4][C:3]1[NH:5][CH:9]=[N:1][C:2]=1[C:6]([NH2:8])=[O:7]

참가 물질

7

반응물 4

HCID 284Formic AcidHCID 313Hydrochloric AcidHCID 31214Ethyl orthoformateHCID 964572-Aminopropanediamide

생성물 1

HCID 178479550HCID 178479550, 화합물

시약·촉매·용매 2

HCID 962Water용매2회HCID 3776Isopropanol용매

반응 조건

온도
80 °C

실험 절차

Under the nitrogen atmosphere, 10 g of 2-aminomalonamide and 19.7 mg of formic acid were added to 200 mL of 2-propanol. After heating to 80° C., 35.4 mL of triethyl orthoformate was added dropwise to the mixture over 5 minutes. Subsequently, the reaction mixture was stirred for 8 hours at 80° C. Color of the reaction liquid was pale blue when the reaction was completed. Subsequently, after cooling to 56° C., the reaction mixture was added with 10 mL of water followed by 8 mL of conc. hydrochloric acid. After cooling with water, the crystal was collected by filtration and then washed with 40 mL of acetone to give 16 g of 5-hydroxy-1H-imidazole-4-carboxamide hydrochloric acid salt dihydrate as a pale yellowish green crystal.

후처리

  1. customColor of the reaction liquid
  2. temperatureSubsequently, after cooling to 56° C.
  3. filtrationthe crystal was collected by filtration
  4. washwashed with 40 mL of acetone

출처 및 근거

ORD 기록
ord-1b69dabac6524e80a14330ee27d18147
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09108928B2

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