Hydrochloric Acid → HCID 178479550, 화합물

HRID 514675

반응식

HRID 514675 반응식
[NH2:1][CH:2]([C:6]([NH2:8])=[O:7])[C:3]([NH2:5])=[O:4].[CH:9](OCC)(OCC)[O:10]CC.CC(O)C.[ClH:23]>O>[OH2:4].[OH2:10].[ClH:23].[OH:4][C:3]1[NH:5][CH:9]=[N:1][C:2]=1[C:6]([NH2:8])=[O:7]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 31214Ethyl orthoformateHCID 964572-Aminopropanediamide

생성물 1

HCID 178479550HCID 178479550, 화합물

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

Under the nitrogen atmosphere, 10 g of 2-aminomalonamide and 35.4 mL of triethyl orthoformate were added to 200 mL of 2-propanol. After heating to 80° C., the reaction mixture was stirred for 13 hours at the same temperature. Color of the reaction liquid was pale blue when the reaction was completed. Subsequently, the reaction mixture was cooled to 58° C., then added with 10 mL of water followed by 8 mL of conc. hydrochloric acid. After cooling the reaction mixture to 5° C., the crystal was collected by filtration and then washed with 40 mL of acetone to give 16 g of 5-hydroxy-1H-imidazole-4-carboxamide hydrochloric acid salt dihydrate as a green crystal.

후처리

  1. customColor of the reaction liquid
  2. temperatureSubsequently, the reaction mixture was cooled to 58° C.
  3. temperatureAfter cooling the reaction mixture to 5° C.
  4. filtrationthe crystal was collected by filtration
  5. washwashed with 40 mL of acetone

출처 및 근거

ORD 기록
ord-695a3715d2b546eb94650678d277c3f0
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09108928B2

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