Hydrochloric Acid → 2-(6-Bromo-2-methylpyrimidin-4-ylamino)thiazole-5-formic acid

HRID 515256노트

반응식

HRID 515256 반응식
[Br:1][C:2]1[N:7]=[C:6]([CH3:8])[N:5]=[C:4]([NH:9][C:10]2[S:11][C:12]([C:15]([O:17]C)=[O:16])=[CH:13][N:14]=2)[CH:3]=1.[OH-].[Na+].Cl>O>[Br:1][C:2]1[N:7]=[C:6]([CH3:8])[N:5]=[C:4]([NH:9][C:10]2[S:11][C:12]([C:15]([OH:17])=[O:16])=[CH:13][N:14]=2)[CH:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 49821806Methyl 2-(6-bromo-2-methylpyrimidin-4-ylamino)thiazole-5-formate2회

생성물 1

HCID 498218842-(6-Bromo-2-methylpyrimidin-4-ylamino)thiazole-5-formic acid수율 78.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Methyl 2-(6-bromo-2-methylpyrimidin-4-ylamino)thiazole-5-formate (Compound 11) (32.9 g, 0.1 mol) was added into a solution of NaOH (8.0 g, 0.2 mol) in water (250 mL) prepared in advance, and reacted by stirring at room temperature overnight. After filtration the filtrate was transferred into reaction flask and pH value was adjusted to 6-6.5 with hydrochloric acid (6N) when the temperature is controlled between 20° C. and 25° C. Grew the grain by stirring for 2 h, and then filtrated and dried to give Compound 12 (21.2 g, yield: 78.3%).

후처리

  1. customprepared in advance
  2. customreacted
  3. filtrationAfter filtration the filtrate
  4. customwas transferred into reaction flask and pH value
  5. customis controlled between 20° C. and 25° C
  6. stirringGrew the grain by stirring for 2 h
  7. filtrationfiltrated
  8. customdried

출처 및 근거

ORD 기록
ord-0235a1831eb142f1a0184a149de35a6a
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09108954B2

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