2-Aminopyridine → N-(5-pyrimidinylmethylene)-2-pyridinamine

HRID 515552

반응식

HRID 515552 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[N:8]1[CH:13]=[C:12]([CH:14]=O)[CH:11]=[N:10][CH:9]=1>C(Cl)(Cl)Cl>[N:8]1[CH:13]=[C:12]([CH:14]=[N:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=2)[CH:11]=[N:10][CH:9]=1

참가 물질

4

반응물 2

HCID 104392-AminopyridineHCID 2761034Pyrimidine-5-carboxaldehyde

생성물 1

HCID 68282155N-(5-pyrimidinylmethylene)-2-pyridinamine수율 99.8%

시약·촉매·용매 1

HCID 6212Chloroform용매3회

실험 절차

A solution of 2-aminopyridine (11.314 g, 120.3 mmol) and pyrimidine-5-carboxaldehyde (14.0 g, 129.6 mmol) in chloroform (300 mL) was stirred at room temperature for 15 min. The volatiles were then removed under reduced pressure (1 h at 75° C.) to yield a yellow solid. The crude solid was dissolved in chloroform (300 mL) and the solution was stirred for 15 min. The volatiles were then removed under reduced pressure (1 h at 75° C.) to yield a yellow solid. The crude solid was again dissolved in chloroform (300 mL), the solution was stirred for 15 min, and the volatiles were removed under reduced pressure (1 h at 85° C.) to yield a yellow solid. This solid was dried in a vacuum oven overnight at 80° C. to yield 22.090 g (99.8%) of the title compound.

후처리

  1. customThe volatiles were then removed under reduced pressure (1 h at 75° C.)
  2. customto yield a yellow solid
  3. customThe volatiles were then removed under reduced pressure (1 h at 75° C.)
  4. customto yield a yellow solid
  5. stirringthe solution was stirred for 15 min
  6. customthe volatiles were removed under reduced pressure (1 h at 85° C.)
  7. customto yield a yellow solid
  8. customThis solid was dried in a vacuum oven overnight at 80° C.

출처 및 근거

ORD 기록
ord-8448ac91cd3e43139bff4f0665ee5357
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09108965B2

연결된 노트

불러오는 중…